Properties are selected based on real traveler reviews and popularity among guests who’ve booked a night in Big Pine Key on Hotels.com. These Big Pine Key hotels consistently deliver on quality, location and traveler experience. Last updated on .
Hotels in Big Pine Key

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1. Southernmost Beach Resort and Guesthouses
Southernmost Beach Resort and GuesthousesOld Town Key West
8.6 out of 10, Excellent, (3,658 reviews)
$286 nightly
The price is $322
Nov 29 - Nov 30
Total with taxes and fees

2. Blue Flamingo Resort Key West
Blue Flamingo Resort Key WestNew Town
8.6 out of 10, Excellent, (2,784 reviews)
$166 nightly
The price is $187
Nov 16 - Nov 17
Total with taxes and fees

3. Parmer's Resort
Parmer's ResortSummerland Key
9.0 out of 10, Wonderful, (1,002 reviews)
$198 nightly
The price is $223
Dec 1 - Dec 2
Total with taxes and fees

4. Isla Bella Beach Resort & Spa
Isla Bella Beach Resort & SpaMarathon
9.2 out of 10, Wonderful, (1,303 reviews)
$310 nightly
The price is $349
Dec 10 - Dec 11
Total with taxes and fees

5. Havana Cabana at Key West
Havana Cabana at Key WestNew Town
9.0 out of 10, Wonderful, (1,909 reviews)
$184 nightly
The price is $207
Nov 30 - Dec 1
Total with taxes and fees

6. Beachside Resort & Residences
Beachside Resort & ResidencesKey West
8.6 out of 10, Excellent, (2,673 reviews)

7. Hyatt Vacation Club at Windward Pointe, Key West
Hyatt Vacation Club at Windward Pointe, Key WestKey West
9.4 out of 10, Exceptional, (1,339 reviews)
$222 nightly
The price is $250
Nov 18 - Nov 19
Total with taxes and fees

8. Margaritaville Beach House Key West
Margaritaville Beach House Key WestKey West
8.8 out of 10, Excellent, (1,823 reviews)
$285 nightly
The price is $321
Nov 18 - Nov 19
Total with taxes and fees

9. DoubleTree Resort by Hilton Grand Key - Key West
DoubleTree Resort by Hilton Grand Key - Key WestKey West
8.4 out of 10, Very good, (1,136 reviews)
$149 nightly
The price is $168
Nov 17 - Nov 18
Total with taxes and fees

10. Casa Marina Key West, Curio Collection by Hilton
Casa Marina Key West, Curio Collection by HiltonOld Town Key West
8.4 out of 10, Very good, (1,020 reviews)
$286 nightly
The price is $322
Nov 23 - Nov 24
Total with taxes and fees

11. Looe Key Reef Resort
Looe Key Reef ResortSummerland Key
7.8 out of 10, Good, (1,001 reviews)
$165 nightly
The price is $186
Nov 20 - Nov 21
Total with taxes and fees

12. Parrot Key Hotel & Villas
Parrot Key Hotel & VillasNorthside Resort
9.0 out of 10, Wonderful, (1,487 reviews)
$200 nightly
The price is $225
Nov 16 - Nov 17
Total with taxes and fees

13. The Reach Key West, Curio Collection by Hilton
The Reach Key West, Curio Collection by HiltonOld Town Key West
8.6 out of 10, Excellent, (1,069 reviews)
$263 nightly
The price is $296
Nov 30 - Dec 1
Total with taxes and fees

14. Hilton Key West Resort & Marina
Hilton Key West Resort & MarinaStock Island
9.0 out of 10, Wonderful, (1,796 reviews)
$170 nightly
The price is $191
Nov 17 - Nov 18
Total with taxes and fees

15. The Perry Hotel & Marina Key West
The Perry Hotel & Marina Key WestStock Island
9.4 out of 10, Exceptional, (1,318 reviews)
$168 nightly
The price is $190
Nov 30 - Dec 1
Total with taxes and fees

16. Hawks Cay Resort
Hawks Cay ResortMarathon
8.2 out of 10, Very good, (1,004 reviews)
$301 nightly
The price is $337
Nov 16 - Nov 17
Total with taxes and fees

17. Hyatt Vacation Club at Beach House, Key West
Hyatt Vacation Club at Beach House, Key WestKey West
9.4 out of 10, Exceptional, (1,290 reviews)
$252 nightly
The price is $283
Nov 29 - Nov 30
Total with taxes and fees

18. Hampton Inn Key West FL
Hampton Inn Key West FLKey West
9.0 out of 10, Wonderful, (1,580 reviews)
$169 nightly
The price is $190
Nov 16 - Nov 17
Total with taxes and fees

19. Hilton Garden Inn Key West / The Keys Collection
Hilton Garden Inn Key West / The Keys CollectionNew Town
8.2 out of 10, Very good, (1,360 reviews)
$140 nightly
The price is $157
Nov 17 - Nov 18
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Go beyond your typical stay in Big Pine Key
Pet friendly
Top neighborhoods in Big Pine Key

Whispering Pines
Whispering Pines in Big Pine Key offers a peaceful escape where you can watch the sunrise from your private dock. Kayak through pristine mangrove channels to spot rays and manatees in crystal-clear waters. Take a short drive to see the tiny Key deer at National Key Deer Refuge or browse the local flea market for unique treasures. The neighborhood features pastel-painted homes with metal roofs and tropical landscaping instead of busy resorts. Vacation rentals and waterfront cottages make perfect home bases for exploring nearby Calusa Beach. You'll need a rental car to reach seafood spots and grocery stores just minutes away.

Long Beach Estates
Long Beach Estates is a Florida Keys paradise where crystal waters meet peaceful streets lined with private homes. Spend your days snorkeling in the clear shallows, kayaking through mangroves, or simply watching ospreys soar overhead from your waterfront deck. The Coupon Bight Aquatic Preserve offers pristine waters teeming with marine life just steps from your door. Most homes feature private docks and full kitchens, perfect for grilling the day's catch as the sun sets. While dining options require a quick drive to Big Pine Key's commercial area, the trade-off is blissful quiet and genuine Keys living. Rental cars are essential for exploring nearby Calusa Beach and the Big Pine Key Flea Market.

Sands
The Sands neighborhood in Big Pine Key lets you live your water-lover dreams without tourist crowds. Kayak through crystal-clear shallows, spot colorful birds at dawn, or fish right from your private dock at the Coupon Bight Aquatic Preserve. Vacation homes on stilts offer peaceful retreats with tropical gardens and glimpses of turquoise water between palm trees and mangroves. Expect to self-cater in well-equipped rental kitchens or drive to nearby dining spots. A rental car is essential for exploring this residential haven and neighboring Keys. The quiet streets invite leisurely walks while the gentle lapping of bay waters creates the perfect soundtrack for your Florida Keys escape.

Eden Pines
Eden Pines offers canal-living at its most blissfully chill. The Big Pine Key neighborhood serves up waterfront homes, crystal-clear canals, and a delicious break from tourist crowds. Spend your mornings spotting local wildlife at nearby Blue Hole, then grab your fishing gear or kayak and explore the peaceful waterways. The lapping waves against wooden docks create a natural soundtrack that'll make you forget about your email inbox completely. Getting around requires a rental car since this is primarily a residential area without commercial spots. Most vacation rentals come with private docks and full kitchens, perfect for cooking up your fresh catch. For dining and shopping, you'll need to venture to Big Pine Key's small commercial district nearby.

Pine Channel Estates
Pine Channel Estates offers a slice of authentic Florida Keys living with its network of scenic canals and private docks. This quiet residential area puts you right on the water with crystal-clear channels perfect for fishing, kayaking, and boat trips to the Atlantic or Gulf. Wildlife enthusiasts will appreciate nearby Blue Hole and the Key Deer Refuge where nature takes center stage. The neighborhood features vacation homes with boat slips and water views, creating a peaceful retreat from tourist crowds. You'll need to drive a quick 5-10 minutes to reach Big Pine Key's markets and eateries. The calm residential streets make for pleasant evening strolls along the waterfront as the sun sets over the mangroves.
Top landmarks in Big Pine Key
Learn more about Big Pine Key
Forget the glitz of Key West – Big Pine Key offers the Florida Keys at their most authentic. Kayak through mangrove tunnels where tiny Key deer (found nowhere else on earth) might peek from the shoreline. The Blue Hole, an abandoned quarry turned freshwater lake, attracts alligators and visitors alike. Snorkel Looe Key's reef where colorful fish dart through coral formations. Bahia Honda State Park boasts beaches ranked among Florida's finest, with shallow waters perfect for novice swimmers. Loggerhead Beach provides a quieter alternative to Calusa Beach. The laid-back atmosphere extends to local fish shacks where the catch arrives hours before hitting your plate. Bring binoculars – the bird watching rivals the people watching.

Check out reviews of Big Pine Key hotels guests love

Fairfield Inn & Suites by Marriott Marathon Florida Keys
8/10 Good
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