Hotels in Greenville

your current months are January, 2025 and February, 2025.
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February 2025
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Where to stay in Greenville?

Learn more about Greenville

The region around Greenville is home to attractions such as Mark Twain National Forest and Lake Wappapello State Park.

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Frequently asked questions

Can I book a refundable accommodation option in Greenville?
If you want the flexibility to change your plans to Greenville, most hotels offer refundable* rates that you can book. You can see these properties by searching our site and using the “fully refundable” filter to narrow down the results.
What will the weather in Greenville be like during my visit?
July and August are typically the warmest months in Greenville, when the average temperature is 25°C. January and February are the coldest months, when the average temperature is 5°C. April and May are the months with the most rain.
Why should I book my Greenville hotel with Hotels.com?
There are lots of reasons to book your Greenville trip with us: our free cancellations on selected hotels* gives you flexibility, our Price Guarantee ensures that you always get the lowest price, and you can earn rewards on every booking.