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Hotels in O Brien

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Where to stay in O Brien?

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about O Brien

O Brien is well known for its attractions such as Suwannee River and Ichetucknee River.

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Frequently asked questions

Can I book a refundable accommodation option in O Brien?
If you want the flexibility to change your plans to O Brien, most hotels offer refundable* rates that you can book. You can find this accommodation by searching our site and using the “fully refundable” filter to narrow the results down.
Where can I stay in O Brien if I want a holiday rental instead of a hotel?
You’ll find 8 holiday homes on our site.
What will the weather in O Brien be like during my visit?
July and August are typically the warmest months in O Brien, when the average temperature is 27°C. January and February are the coldest months, when the average temperature is 14°C. June and August are the months with the most rain.
Why should I book my O Brien hotel with Hotels.com?
There are lots of reasons to book your O Brien trip with us: our free cancellations on selected hotels* gives you flexibility, our Price Guarantee ensures that you always get the lowest price, and you can earn rewards on every booking.