Hotels in O Brien

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Where to stay in O Brien?

Properties are selected based on real traveler reviews and popularity among guests who’ve booked a night in O Brien on Hotels.com. These O Brien hotels consistently deliver on quality, location and traveler experience. Last updated on .

1. Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
3.5 star property
Alachua
9.4 out of 10, Exceptional, (1,002 reviews)
Sink into comfort at this Alachua hotel near sports venues and community center. Start your day with a free breakfast before exploring local attractions. The helpful staff, pool, and well-equipped rooms with refrigerators and microwaves make for a convenient stay.
$100 nightly
The price is $113
Dec 14 - Dec 15
Total with taxes and fees
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

2. Best Western Plus Lake City

Best Western Plus Lake City
2.5 star property
Lake City
9.0 out of 10, Wonderful, (1,139 reviews)
Located minutes from Lake City Mall and Regal UA Cinema 90, this welcoming hotel offers an indoor pool and fitness center. Enjoy free WiFi, parking, and breakfast before exploring the area. Business travelers appreciate the friendly staff.
$80 nightly
The price is $90
Dec 1 - Dec 2
Total with taxes and fees
Best Western Plus Lake City

3. La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City
3.0 star property
Lake City
8.8 out of 10, Excellent, (1,208 reviews)
This business-friendly Lake City hotel offers 24-hour fitness options alongside free breakfast, WiFi, and parking. Near Regal UA Cinema 90 and Lake City Mall, the indoor pool invites year-round swimming after exploring local attractions.
$94 nightly
The price is $105
Dec 2 - Dec 3
Total with taxes and fees
La Quinta Inn & Suite by Wyndham Lake City

4. Tru by Hilton Lake City

Tru by Hilton Lake City
2.5 star property
Lake City
9.2 out of 10, Wonderful, (1,001 reviews)
Dive into comfort at this Lake City hotel with an outdoor swimming pool. Work out in the fitness center after enjoying a free breakfast. Near Regal UA Cinema 90 and Lake City Mall, with helpful staff and complimentary WiFi and parking.
$93 nightly
The price is $105
Dec 6 - Dec 7
Total with taxes and fees
Tru by Hilton Lake City

5. Comfort Suites Lake City

Comfort Suites Lake City
2.5 star property
Lake City
9.4 out of 10, Exceptional, (1,001 reviews)
Escape to this welcoming Lake City hotel where an outdoor pool provides refreshing relaxation. Located near Regal UA Cinema 90 and Lake City Mall, guests rave about the free breakfast and helpful staff.
$94 nightly
The price is $105
Dec 6 - Dec 7
Total with taxes and fees
Comfort Suites Lake City

6. Quality Inn Alachua - Gainesville Area

Quality Inn Alachua - Gainesville Area
2.5 star property
Alachua
7.2 out of 10, Good, (1,009 reviews)
$72 nightly
The price is $81
Nov 22 - Nov 23
Total with taxes and fees
Quality Inn Alachua - Gainesville Area

7. The Blanche

The Blanche
2.0 star property
Lake City
9.4 out of 10, Exceptional, (207 reviews)
Sink into premium bedding after exploring Lake City Columbia County Historical Museum. This hotel offers free WiFi and in-room coffeemakers, with Lake DeSoto Farmers Market just minutes away. Perfect for comfortable, convenient stays.
$149 nightly
The price is $167
Nov 16 - Nov 17
Total with taxes and fees
The Blanche

8. Holiday Inn & Suites Lake City by IHG

Holiday Inn & Suites Lake City by IHG
3.0 star property
Lake City
8.6 out of 10, Excellent, (1,001 reviews)
At this Lake City hotel, unwind in the indoor pool after a workout in the 24-hour fitness center. The Atrium restaurant serves American cuisine, while the bar offers evening relaxation. Located near Regal UA Cinema 90 and Lake City Mall with free WiFi and parking.
$93 nightly
The price is $105
Dec 13 - Dec 14
Total with taxes and fees
Holiday Inn & Suites Lake City by IHG

9. Hampton Inn & Suites Alachua I-75

Hampton Inn & Suites Alachua I-75
2.5 star property
Alachua
9.4 out of 10, Exceptional, (572 reviews)
Cool off in the outdoor pool of this Alachua hotel after exploring nearby attractions. The fitness center, free parking, and 24-hour front desk ensure convenience, while clean rooms provide a comfortable base for your Florida adventures.
$114 nightly
The price is $128
Nov 29 - Nov 30
Total with taxes and fees
Hampton Inn & Suites Alachua I-75

10. Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City
2.5 star property
Lake City
9.4 out of 10, Exceptional, (1,000 reviews)
Just off I-75, this welcoming hotel offers a refreshing outdoor pool and fitness center near Regal UA Cinema 90 and Lake City Mall. Enjoy free breakfast, WiFi, and parking, while the helpful staff ensures a clean, comfortable business stay.
$98 nightly
The price is $110
Dec 13 - Dec 14
Total with taxes and fees
Hampton Inn & Suites Lake City

11. Courtyard By Marriott Lake City

Courtyard By Marriott Lake City
3.0 star property
Lake City
9.6 out of 10, Exceptional, (315 reviews)
Unwind at this Lake City gem with an outdoor pool and on-site café. Grab a drink at the bar after exploring Regal UA Cinema 90 and Lake City Mall. Business travelers will appreciate free WiFi and parking.
$107 nightly
The price is $120
Nov 22 - Nov 23
Total with taxes and fees
Courtyard By Marriott Lake City

12. Quality Inn Lake City

Quality Inn Lake City
2.5 star property
Lake City
8.2 out of 10, Very good, (1,002 reviews)
Enjoy the outdoor pool and fitness center at this welcoming Lake City lodging. Clean rooms provide restful stays near Regal UA Cinema 90 and Lake City Mall. The attentive staff, free breakfast, WiFi, and parking enhance your travel experience.
$69 nightly
The price is $77
Dec 13 - Dec 14
Total with taxes and fees
Quality Inn Lake City

13. BlueGem Motel

BlueGem Motel
2.0 star property
High Springs
9.2 out of 10, Wonderful, (488 reviews)
Discover the BlueGem Motel's charm with free WiFi and parking. This cozy retreat puts you near High Springs Civic Center Park and Museum. Travelers praise the spotless rooms and friendly service for a relaxing Florida getaway.
$96 nightly
The price is $108
Nov 16 - Nov 17
Total with taxes and fees
BlueGem Motel

14. Fairfield Inn & Suites Lake City

Fairfield Inn & Suites Lake City
3.0 star property
Lake City
9.0 out of 10, Wonderful, (300 reviews)
Wake up to complimentary breakfast at this Lake City hotel, where the indoor pool and hot tub create perfect relaxation spots. Just minutes from Regal UA Cinema 90 and local shopping, enjoy free WiFi and parking with business-friendly amenities.
$94 nightly
The price is $106
Dec 5 - Dec 6
Total with taxes and fees
Fairfield Inn & Suites Lake City

15. Americas Best Value Inn Lake City

Americas Best Value Inn Lake City
2.0 star property
Lake City
8.6 out of 10, Excellent, (1,000 reviews)
Close to Regal UA Cinema 90 and Lake City Mall, this motel welcomes travelers with an outdoor pool and complimentary perks. Free WiFi, parking, and daily breakfast from 6:00 AM make for exceptional value.
$71 nightly
The price is $80
Nov 15 - Nov 16
Total with taxes and fees
Americas Best Value Inn Lake City

16. Suwannee River Rendezvous

Suwannee River Rendezvous
2.5 star property
Mayo
8.6 out of 10, Excellent, (34 reviews)
Relax at this serene Mayo retreat along the Suwannee River, offering 3 outdoor pools and convenient dining at The Cookin' Shack. Explore nearby Peacock Springs State Park while enjoying free WiFi and parking throughout your stay.
$123 nightly
The price is $131
Nov 17 - Nov 18
Total with taxes and fees
Suwannee River Rendezvous

17. Motel 6 – Lake City, Fl – Medical Center

Motel 6 – Lake City, Fl – Medical Center
2.0 star property
Lake City
7.4 out of 10, Good, (251 reviews)
Vibrant Lake City motel with 24-hour front desk and free WiFi, perfect for travelers exploring north Florida. Located near Regal UA Cinema 90 and Lake City Mall, with convenient access to medical facilities and free parking.
$73 nightly
The price is $82
Dec 1 - Dec 2
Total with taxes and fees
Motel 6 – Lake City, Fl – Medical Center

18. Home2 Suites by Hilton Lake City

Home2 Suites by Hilton Lake City
3.0 star property
Lake City
9.4 out of 10, Exceptional, (834 reviews)
This quiet Lake City hotel offers convenient access to Regal UA Cinema 90 and Lake City Mall. Enjoy the outdoor pool, snack bar, and free breakfast. Rooms feature sofa beds and refrigerators, while a terrace and fitness center enhance your peaceful stay.
$119 nightly
The price is $134
Nov 22 - Nov 23
Total with taxes and fees
Home2 Suites by Hilton Lake City

19. Super 8 by Wyndham Lake City

Super 8 by Wyndham Lake City
2.0 star property
Lake City
7.4 out of 10, Good, (767 reviews)
Dive into the refreshing outdoor pool at this Lake City motel. Enjoy free WiFi, complimentary parking, and cooked-to-order breakfast daily from 6-9 AM. Near North Florida Speedway and Southside Sports Complex, with staff that guests consistently praise for their helpfulness.
$61 nightly
The price is $69
Dec 1 - Dec 2
Total with taxes and fees
Super 8 by Wyndham Lake City

20. Baymont by Wyndham Lake City I-75

Baymont by Wyndham Lake City I-75
2.5 star property
Lake City
5.0 out of 10, (1,001 reviews)
Just off I-75, this welcoming hotel offers free breakfast, WiFi, and parking. Catch a movie at nearby Regal UA Cinema 90 or shop at Lake City Mall. All rooms include refrigerators and microwaves for added convenience.
$58 nightly
The price is $65
Nov 15 - Nov 16
Total with taxes and fees
Baymont by Wyndham Lake City I-75
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about O Brien

O Brien is well-known for its attractions such as Suwannee River and Ichetucknee River.

A calm river surrounded by trees reflecting in the water.

Check out reviews of O Brien hotels guests love

Frequently asked questions

How much does a hotel room cost in O Brien?
You can choose a great hotel in O Brien from $55 with properties to suit all budgets and needs. To find an affordable hotel in O Brien that meets all of your requirements, just apply filters on Hotels.com and sort hotels by "Price: low to high".
How can I find deals and earn rewards at O Brien hotels?
Discover great deals on O Brien hotel stays with Hotels.com. Take a look at hotel prices mid-week or during the low season as to find those off-peak deals. If you're up for a spontaneous trip, don't forget to check out our last-minute deals on O Brien hotels.
Can I book O Brien hotels with free cancellation?
In order to book a refundable O Brien hotel, simply filter hotels by "Property cancellation options" and select "Fully refundable property". Most hotels offer free cancellation, so you can receive a refund if you need to cancel. Some hotels do require cancelling more than 24 hours before check-in, so double-check your booking beforehand.
Can I book refundable hotels in O Brien?
If you want the flexibility to change your travel plans to O Brien, most accommodations provide refundable* bookable rates. You can find these accommodations by searching our site and using the "fully refundable" filter to narrow the results down.
Where can I stay in O Brien if I want a vacation home instead of a traditional hotel?
You'll find 5 vacation homes on our site.
What will the weather in O Brien be like during my vacation?
July and August are typically the warmest months in O Brien when the average temp is 80°F. January and February are the coldest months when the average temperature is 58°F. June and August are the months with the most rain.
Why should I book my O Brien hotel with Hotels.com?
There are lots of reasons to book your O Brien trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Find out more about O Brien

Discover the Enchantment of O'Brien: Nature's Hidden Gem by the Water

Nestled in the serene landscapes of North Florida, O'Brien is a hidden gem for nature enthusiasts and adventure seekers alike. Surrounded by lush greenery and the tranquil waters of the Suwannee River, this charming town offers access to the breathtaking Big Shoals State Park, known for its scenic trails and exciting whitewater rapids. Visitors can enjoy swimming in pristine waterholes, fishing, and kayaking in the river’s crystal-clear waters. O'Brien’s peaceful ambiance and stunning natural beauty make it the perfect off-the-beaten-path escape for those looking to unwind and connect with nature.

Discover great hotels near O Brien

O'Brien, Florida offers a range of accommodations, from cozy vacation rentals and charming bed and breakfasts to comfortable hotels. Visitors can enjoy a peaceful stay surrounded by nature, with options suitable for families, couples, or solo travelers looking to explore the scenic beauty of the area. These are some of the hotels preferred by our travelers near O Brien:

  1. Cindys MotelOpens in a new window: This budget-friendly motel is an ideal choice for leisure travelers seeking comfort and convenience. With a guest rating of 8.8 out of 10, Cindys Motel provides easy parking and a safe environment that appeals to travelers. The motel features comfortable beds and a straightforward check-in process, ensuring a smooth arrival. Visitors appreciate the pet-friendly policies, making it a distinctive option for those traveling with pets. The inviting atmosphere and positive guest experiences emphasize the hotel's commitment to a pleasant stay.
  2. Motel 8 Lake CityOpens in a new window: Motel 8 Lake City is a budget-friendly motel that serves as an excellent retreat for leisure travelers. This property allows pets, providing a unique experience for those looking to travel with their furry companions. The easy access and welcoming ambiance contribute to a hassle-free stay. Rated highly by guests, Motel 8 Lake City showcases a commitment to comfort and convenience, making it an attractive choice for those exploring the area. The thoughtful amenities ensure that travelers can enjoy a relaxed and enjoyable experience throughout their visit.
  3. Americas Best Value Inn Lake CityOpens in a new window: With a guest rating of 8.6 out of 10, Americas Best Value Inn Lake City caters to leisure travelers seeking a comfortable and enjoyable stay. This budget-friendly motel is known for its friendly staff and well-maintained facilities, including remodeled rooms with cozy beds. Guests appreciate the complimentary breakfast options, adding to the overall appeal of the hotel. The inviting and clean environment, combined with a focus on guest satisfaction, positions Americas Best Value Inn Lake City as a delightful choice for those looking to unwind and explore the local area.

Where to stay near O Brien

When visiting O'Brien, Florida, consider staying in Branford, Alton, or Mcalpin. Branford is family-friendly with plenty of outdoor activities, while Alton offers unique points of interest that appeal to diverse travelers. Mcalpin provides a tranquil setting ideal for relaxation. For first-time visitors, Branford is the best choice due to its welcoming atmosphere and recreational opportunities.

  1. BranfordOpens in a new window: Branford is a charming destination known for its family-friendly atmosphere and outdoor activities. Nestled along the banks of the Suwannee River, this area is perfect for those who enjoy swimming, fishing, and kayaking. The nearby Ichetucknee Springs State Park offers crystal-clear waters for tubing and snorkeling, making it a refreshing getaway. With its small-town charm, Branford also hosts local events that bring the community together, providing a taste of the local culture and hospitality.
  2. McalpinOpens in a new window: Mcalpin is a quaint and peaceful spot that offers a laid-back vibe perfect for relaxation. Surrounded by the natural beauty of Florida’s landscapes, it’s an ideal base for exploring nearby parks and trails. Enjoy leisurely walks or bike rides while taking in the scenic views. The area is rich in wildlife and plant life, making it a great choice for nature enthusiasts looking to unwind in a serene setting.
  3. AltonOpens in a new window: Alton is a hidden gem that embodies the essence of rural Florida living. With its serene environment, visitors can enjoy a slower pace, perfect for escaping the hustle and bustle. The scenic countryside offers opportunities for hiking and bird watching, allowing you to connect with nature. Alton is also close to various local attractions, making it convenient for day trips while providing a peaceful retreat to return to at night.

Things to do in and around O Brien

O'Brien is a hidden gem for nature lovers, featuring stunning river landscapes, lush national parks, and serene waterholes. Visitors can enjoy exciting outdoor activities like hiking through forests, boating on tranquil lakes, and diving in crystal-clear waters. It's an ideal spot for relaxation and adventure alike!

  • Stephen Foster Folk Culture Center State ParkOpens in a new window – Dive into Florida's rich heritage at this national state park. Explore the stunning landscapes along the river and enjoy the tranquil water features. The park often hosts cultural events, making it a great spot to experience local traditions while surrounded by nature.
  • Blue Sink Canoe LaunchOpens in a new window – Launch your canoe or kayak at this picturesque marina, where the clear waters beckon adventurers. Paddle through the scenic waterways and soak in the natural beauty of the area. Keep an eye out for local wildlife as you glide along the river.
  • Wes Skiles Peacock Springs State ParkOpens in a new window – Known for its enchanting underwater springs, this national state park is a paradise for snorkelers and divers. Venture into the crystal-clear waters and appreciate the unique aquatic life. The park also offers hiking trails if you prefer to stay above water.
  • Troy Spring State ParkOpens in a new window – Experience the refreshing waters of Troy Spring, a perfect spot for swimming and picnicking. This national state park features a scenic backdrop that is ideal for a leisurely day outdoors. Bring your lunch and relax as you listen to the sounds of nature.
  • Lafayette Blue Springs State ParkOpens in a new window – Unwind at this beautiful national state park, where you can swim in the cool springs or enjoy a family-friendly picnic. With lush greenery surrounding the water, it’s a perfect getaway to reconnect with nature and enjoy some fun in the sun.

5 tips for savvy savings when booking a hotel in O Brien

  1. Book for the cheapest times: The most budget-friendly months to visit O'Brien are January, August, and November, when hotel prices are lower. For a great value for money experience, it's best to stay for at least 2 to 3 days to fully explore the area's key landmarks, historical sites, and cultural attractions. During your visit, you can enjoy a variety of activities, such as relaxing at beautiful beaches known for their wildlife and stunning sunsets, visiting the local aquarium, or taking a stroll through the modern square. With plenty of options available, O'Brien offers an affordable getaway that is perfect for those on a budget.
  2. Instant discounts. Rewards for later: Save up to 20% instantly on hundreds of thousands of properties with Member Discounts. Then earn rewards on eligible stays to use on future trips. Book once, win twice, get instant discounts and rewards. Join for freeOpens in a new window.
  3. Score last-minute deals on Hotels.com: Last-minute travel doesn't mean last-minute stress. Hotels.com's Last-Minute DealsOpens in a new window offer discounted rates close to your travel date, so the later you leave it, the more you could save. Turn on push notifications and you'll be the first to know when dealsOpens in a new window drop for O Brien.
  4. Book with confidence, not guesswork: Prices in O Brien shift with the season, local events, and how far out you book — but you don't have to guess. Hotels.com shows you the full price upfront with no surprises at checkout, and our price tracker tells you whether your dates are above or below average. So if you're flexible, you can shift your trip by a day or two to avoid peak season prices, compare pricesOpens in a new window and know you're getting a good deal before you commit.
  5. Think beyond the city center: Central hotels may come with a central price tag. A well-connected neighborhood a little further out may cut your hotel bill and can often give you a more local experience. Use Hotels.com's map view to find the sweet spot between location and value, and filter by price to see what's available across O Brien.

Best time to go to O Brien

O Brien experiences its lowest average temperature in January, at 53.4°F (11.9°C), while July is the hottest month, with an average temperature of 81.5°F (27.5°C). June tends to be the wettest month. The peak travel months to visit O Brien are June to August, which see a higher number of tourists. During this peak period, the weather is mostly sunny, accompanied by light rainfall. In contrast, May, and November are ideal if you're looking for a calmer vacation, marked by light rainfall and mostly sunny conditions.

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