Properties are selected based on real traveler reviews and popularity among guests who’ve booked a night in O Brien on Hotels.com. These O Brien hotels consistently deliver on quality, location and traveler experience. Last updated on .
Hotels in O Brien

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Where to stay in O Brien?

1. Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Holiday Inn Express & Suites Alachua - Gainesville Area by IHGAlachua
9.4 out of 10, Exceptional, (1,002 reviews)
$100 nightly
The price is $113
Dec 14 - Dec 15
Total with taxes and fees

2. Best Western Plus Lake City
Best Western Plus Lake CityLake City
9.0 out of 10, Wonderful, (1,139 reviews)
$80 nightly
The price is $90
Dec 1 - Dec 2
Total with taxes and fees

3. La Quinta Inn & Suite by Wyndham Lake City
La Quinta Inn & Suite by Wyndham Lake CityLake City
8.8 out of 10, Excellent, (1,208 reviews)
$94 nightly
The price is $105
Dec 2 - Dec 3
Total with taxes and fees

4. Tru by Hilton Lake City
Tru by Hilton Lake CityLake City
9.2 out of 10, Wonderful, (1,001 reviews)
$93 nightly
The price is $105
Dec 6 - Dec 7
Total with taxes and fees

5. Comfort Suites Lake City
Comfort Suites Lake CityLake City
9.4 out of 10, Exceptional, (1,001 reviews)
$94 nightly
The price is $105
Dec 6 - Dec 7
Total with taxes and fees

6. Quality Inn Alachua - Gainesville Area
Quality Inn Alachua - Gainesville AreaAlachua
7.2 out of 10, Good, (1,009 reviews)
$72 nightly
The price is $81
Nov 22 - Nov 23
Total with taxes and fees

7. The Blanche
The BlancheLake City
9.4 out of 10, Exceptional, (207 reviews)
$149 nightly
The price is $167
Nov 16 - Nov 17
Total with taxes and fees

8. Holiday Inn & Suites Lake City by IHG
Holiday Inn & Suites Lake City by IHGLake City
8.6 out of 10, Excellent, (1,001 reviews)
$93 nightly
The price is $105
Dec 13 - Dec 14
Total with taxes and fees

9. Hampton Inn & Suites Alachua I-75
Hampton Inn & Suites Alachua I-75Alachua
9.4 out of 10, Exceptional, (572 reviews)
$114 nightly
The price is $128
Nov 29 - Nov 30
Total with taxes and fees

10. Hampton Inn & Suites Lake City
Hampton Inn & Suites Lake CityLake City
9.4 out of 10, Exceptional, (1,000 reviews)
$98 nightly
The price is $110
Dec 13 - Dec 14
Total with taxes and fees

11. Courtyard By Marriott Lake City
Courtyard By Marriott Lake CityLake City
9.6 out of 10, Exceptional, (315 reviews)
$107 nightly
The price is $120
Nov 22 - Nov 23
Total with taxes and fees

12. Quality Inn Lake City
Quality Inn Lake CityLake City
8.2 out of 10, Very good, (1,002 reviews)
$69 nightly
The price is $77
Dec 13 - Dec 14
Total with taxes and fees

13. BlueGem Motel
BlueGem MotelHigh Springs
9.2 out of 10, Wonderful, (488 reviews)
$96 nightly
The price is $108
Nov 16 - Nov 17
Total with taxes and fees

14. Fairfield Inn & Suites Lake City
Fairfield Inn & Suites Lake CityLake City
9.0 out of 10, Wonderful, (300 reviews)
$94 nightly
The price is $106
Dec 5 - Dec 6
Total with taxes and fees

15. Americas Best Value Inn Lake City
Americas Best Value Inn Lake CityLake City
8.6 out of 10, Excellent, (1,000 reviews)
$71 nightly
The price is $80
Nov 15 - Nov 16
Total with taxes and fees

16. Suwannee River Rendezvous
Suwannee River RendezvousMayo
8.6 out of 10, Excellent, (34 reviews)
$123 nightly
The price is $131
Nov 17 - Nov 18
Total with taxes and fees

17. Motel 6 – Lake City, Fl – Medical Center
Motel 6 – Lake City, Fl – Medical CenterLake City
7.4 out of 10, Good, (251 reviews)
$73 nightly
The price is $82
Dec 1 - Dec 2
Total with taxes and fees

18. Home2 Suites by Hilton Lake City
Home2 Suites by Hilton Lake CityLake City
9.4 out of 10, Exceptional, (834 reviews)
$119 nightly
The price is $134
Nov 22 - Nov 23
Total with taxes and fees

19. Super 8 by Wyndham Lake City
Super 8 by Wyndham Lake CityLake City
7.4 out of 10, Good, (767 reviews)
$61 nightly
The price is $69
Dec 1 - Dec 2
Total with taxes and fees

20. Baymont by Wyndham Lake City I-75
Baymont by Wyndham Lake City I-75Lake City
5.0 out of 10, (1,001 reviews)
$58 nightly
The price is $65
Nov 15 - Nov 16
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Go beyond your typical stay in O Brien
Pet friendly
Family friendly
Learn more about O Brien
O Brien is well-known for its attractions such as Suwannee River and Ichetucknee River.

Check out reviews of O Brien hotels guests love

Tru by Hilton Lake City
10/10 Excellent
Frequently asked questions
Find out more about O Brien
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