Hotels in Santee

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Check prices for these dates

Tonight
15 Nov - 16 Nov
Tomorrow
16 Nov - 17 Nov
Next weekend
20 Nov - 22 Nov
In two weeks
27 Nov - 29 Nov

Where to stay in Santee?

Properties are selected based on real traveller reviews and popularity among guests who’ve booked a night in Santee on Hotels.com. These Santee hotels consistently deliver on quality, location and traveller experience. Last updated on 16 November 2026.
A spacious kitchen with a large island, modern pendant lights, and a ceiling fan.

1. Lewis and Clark Resort

Lewis and Clark Resort
2.5 star property
Yankton
8.8 out of 10, Excellent, (357 reviews)
Set along Lewis and Clark Lake, this resort combines outdoor adventure with comfortable accommodation. Access the marina directly, cool off in the seasonal pool, then enjoy a meal at the restaurant. Free WiFi and parking make exploring nearby recreation areas effortless.
The price is AU$169
includes taxes & fees
16 Nov - 17 Nov
Lewis and Clark Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Go beyond your typical stay in Santee

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Pet friendly
Pet friendly
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Frequently Asked Questions

How much does a hotel room cost in Santee?

You can discover great hotels in Santee from AU$168 with properties to suit all budgets and needs. If you're after an affordable hotel in Santee that meets all of your requirements, set your filters and then sort the results by "Price: low to high".

How can I find deals and earn rewards at Santee hotels?

Discover great deals on Santee hotel stays with Hotels.com. It's also a good idea to look at hotel prices mid-week or during the low season as you're likely to find off-peak deals. If you're up for a spontaneous trip, don't forget to check out our last-minute deals on Santee hotels.

Can I book Santee hotels with free cancellation?

In order to book a refundable Santee hotel, simply filter hotels by "Property cancellation options" and select "Fully refundable property". The majority of hotels offer free cancellation, so you can receive a refund if you need to cancel. Some hotels do require cancelling more than 24 hours before check-in, so double-check your booking beforehand.

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