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Hotels in Roxana

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Dates

November 2026

December 2026

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Where to stay in Roxana?

Properties are selected based on real traveller reviews and popularity among guests who’ve booked a night in Roxana on Hotels.com. These Roxana hotels consistently deliver on quality, location and traveller experience. Last updated on 10 November 2026.

A modern lobby with patterned armchairs, a fireplace, and a large TV on the wall.

1. Holiday Inn Express & Suites Edwardsville by IHG

Edwardsville

includes taxes & fees

22 Nov - 23 Nov

An outdoor patio with a circular fire pit, seating, and a grill area.

2. TownePlace Suites by Marriott St. Louis Edwardsville, IL

Edwardsville

includes taxes & fees

29 Nov - 30 Nov

A hotel lobby with blue seating, a flat-screen TV, and a fireplace.

3. Comfort Inn Edwardsville - St. Louis

Edwardsville

includes taxes & fees

29 Nov - 30 Nov

A snack and beverage section with shelves stocked with various snacks and drinks, and a wall with a geometric design and text.

4. Hampton Inn & Suites St. Louis/Alton

Alton

includes taxes & fees

29 Nov - 30 Nov

A hotel room with two beds, a desk, a dresser, and a bathroom visible through an open door.

5. Country Hearth Inn & Suites Edwardsville St. Louis

Edwardsville

includes taxes & fees

10 Nov - 11 Nov

A modern bathroom with a red bathtub, a white sink, and a shower. There is a bed with a white mattress and a grey curtain in the adjacent room.

6. Red Lion Inn & Suites Pontoon Beach

Granite City

includes taxes & fees

10 Nov - 11 Nov

A hotel entrance with a covered driveway and a parking area.

7. Best Western Plus Parkway Hotel

Alton

includes taxes & fees

11 Nov - 12 Nov

A modern living room with a stone fireplace, a reception desk, and a large window.

8. Fairfield Inn & Suites St. Louis Pontoon Beach/Granite City

Granite City

includes taxes & fees

15 Nov - 16 Nov

A modern lobby with a stone wall, seating area, and a fireplace.

9. The Great Rivers, an Ascend Collection Hotel

Alton

includes taxes & fees

29 Nov - 30 Nov

A spacious lobby with a high ceiling, large windows, and a variety of seating options including sofas and chairs.

10. Drury Inn & Suites St. Louis Collinsville

Eastport

includes taxes & fees

22 Nov - 23 Nov

A Holiday Inn Express & Suites building with a modern design, featuring a covered entrance and a landscaped area with trees.

11. Holiday Inn Express and Suites Alton St Louis Area by IHG

Alton

includes taxes & fees

29 Nov - 30 Nov

An indoor swimming pool with a lifeguard chair, a lifebuoy, and a mural of a beach scene.

12. Super 8 by Wyndham Troy IL/St. Louis Area

Troy

includes taxes & fees

7 Dec - 8 Dec

A lobby with a blue sofa, patterned cushions, a reception desk, and a mural of a moon and arch.

13. La Quinta Inn & Suites by Wyndham Pontoon Beach

Granite City

includes taxes & fees

15 Nov - 16 Nov

A buffet area with a wooden counter, various food items, and a coffee station.

14. Comfort Inn Collinsville near St. Louis

Eastport

includes taxes & fees

29 Nov - 30 Nov

A hotel room with two beds, a desk, a chair, and a TV.

15. Hampton Inn Collinsville

Eastport

includes taxes & fees

6 Dec - 7 Dec

A spacious lobby with a high ceiling, a chandelier, a seating area with patterned sofas, and a vending machine.

16. Red Roof Inn St Louis - Troy, IL

Troy

includes taxes & fees

16 Nov - 17 Nov

A modern indoor pool area with a blue ceiling, large windows, and a pool with a metal ladder.

17. Hampton Inn O'Fallon

O'Fallon

includes taxes & fees

15 Nov - 16 Nov

A snack kiosk with a variety of packaged foods and beverages, a cash register, and a sign reading 'The Shop.'

18. Hilton Garden Inn St. Louis Airport

Berkeley

includes taxes & fees

27 Nov - 28 Nov

A modern living room with a built-in fireplace, a large flat-screen TV, a unique hexagonal pendant light, and a patterned rug.

19. Hyatt Select St. Louis Airport

Woodson Terrace

includes taxes & fees

11 Nov - 12 Nov

A modern lounge area with a sectional sofa, ottomans, and a round table.

20. Drury Inn & Suites St. Louis Fairview Heights

Fairview Heights

includes taxes & fees

15 Nov - 16 Nov

View all properties

Go beyond your typical stay in Roxana

Top landmarks in Roxana

Wood River Refinery History Museum

Wood River Refinery History Museum is 0.8 mi (1.3 km) from central Roxana, why not stop by during your stay? If you want to experience more of the culture Roxana has to offer, head to Lewis and Clark Confluence Tower, Lewis and Clark Interpretive Center, and Jones-Confluence Point State Park.

See properties

Check out reviews of Roxana hotels guests love

Red Lion Inn & Suites Pontoon Beach

Granite City

10/10 Exceptional

Hamilee

A rooftop terrace with wicker furniture, offering a city view.

Drury Plaza Hotel St. Louis at the Arch

Downtown St. Louis

10/10 Exceptional

Wendy

Comfort Inn Collinsville near St. Louis

Eastport

10/10 Exceptional

I would definitely recommend this property. I found the hotel to be very clean and the staff very friendly. There is a lovely atrium area which is a great space particularly at breakfast time. There are several eateries close by and a fun little mini golf range. The room was spacious and the linen and towels were all very clean. It is located only a 15 minute drive from downtown St Louis but is a great alternative to staying in far more expensive properties closer to the city.

Marto

A spacious lobby with modern seating, a reception desk, and large windows offering views of the parking area.

Pear Tree Inn St. Louis Airport

St. Ann

10/10 Exceptional

Shayne

Frequently Asked Questions

How much does a hotel room cost in Roxana?

You can find top hotels in Roxana from AU$103 with options to suit your budget and needs. If you're looking for an affordable hotel in Roxana that meets all of your requirements, just sort hotels by "Price: low to high" after applying your filters when searching on Hotels.com.

How can I find deals and earn rewards at Roxana hotels?

Discover great deals on Roxana hotel stays with Hotels.com. You can also look at hotel prices mid-week or during the low season to find off-peak deals. And make sure to check out our last-minute deals on Roxana hotels.

Can I book Roxana hotels with free cancellation?

To book a refundable Roxana hotel on Hotels.com, just filter hotels by "Property cancellation options" and select "Fully refundable property". Most hotels offer free cancellation, so you can receive a refund if you need to cancel. Some hotels do require cancelling more than 24 hours before check-in, so double-check your booking beforehand.

What are some popular hotels in central Roxana?

If you're looking for hotels in central Roxana, check out TownePlace Suites by Marriott St. Louis Edwardsville, IL and Bel Air Motel. Travellers love TownePlace Suites by Marriott St. Louis Edwardsville, IL for its location, as well as the indoor pool, free buffet breakfast and 24-hour gym this hotel offers. Bel Air Motel is another popular central motel with free parking, plus free WiFi in the guestrooms.

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