Historic Main Street Hotel Accommodation

Search 96 hotels in Historic Main Street

Hotels.com™ Rewards

Collect 10 nights, get 1 reward night

And look out for Secret Prices on selected hotels

  • Pay now or later on most rooms
  • Free cancellation on most rooms
  • Price Guarantee

Discover Historic Main Street

You can learn about the local heritage of Historic Main Street at landmarks like First Missouri State Capitol Historic Site and Lewis & Clark Boathouse and Nature Center. Historic Main Street is an inviting destination that has something for everyone.